Copper-catalyzed oxidative ring closure and carboarylation of 2-ethynylanilides.

Synthesis of Dibenzofurans via a Palladium Catalyzed Oxidative Ring Closure Reaction

Palladium-catalyzed highly regioselective 6-exo-dig cyclization and alkenylation of ortho-ethynylanilides: the synthesis of polyene-substituted benzo[d][1,3]oxazines.

A Pd-catalyzed highly regioselective 6-exo-dig cyclization/alkenylation reaction of ortho-ethynylanilides has been developed. This tandem cross-coupling protocol represents a simple, efficient, step- and atom-economic approach for the construction of scarcely known polyene-substituted benzo[d][1,3]oxazines in moderate to excellent yields with a broad substrate scope.

Effect of Lycopene on Formation of Low Density Lipoprotein-Copper Complex in Copper Catalyzed Peroxidation of Low Density Lipoprotein, as in vitro Experiment

Background: A great deal of evidence has indicated that oxidatively modified LDL plays a critical role in the initiation and progression of atherosclerosis. Antioxidants that can prevent LDL oxidation may act as antiatherogens. Copper is a candidate for oxidizing LDL in atherosclerotic lesions. The binding of copper ions to LDL is usually thought to be a prerequisite for LDL oxidation by copper...

Functional diversity of 2-oxoglutarate/Fe(II)-dependent dioxygenases in plant metabolism

Oxidative enzymes catalyze many different reactions in plant metabolism. Among this suite of enzymes are the 2-oxoglutarate/Fe(II)-dependent dioxygenases (2-ODDs). Cytochromes P450 (CYPs) as often considered the most versatile oxidative enzymes in nature, but the diversity and complexity of reactions catalyzed by 2-ODDs is superior to the CYPs. The list of oxidative reactions catalyzed by 2-ODD...

Chem. Pharm. Bull. 54(2) 226—229 (2006)

have attracted considerable attention recently for their antioxidative and antimutagenic activities (Chart 1). Lignans are generally accessible only through multistep syntheses and/or direct isolation from the living plant. Lyoniresinol (1) was isolated via extraction of the Lyonia ovalifolia var. elliptica plant. Compound 1 was also obtained by enzymatic hydrolysis of lyoniresinol glucoside wi...